The General Hospital Corporation d/b/a Massachusetts General Hospital;RaNA Therapeutics; Inc.;RaNA Therapeutics, Inc.
发明人:
Krieg, Arthur M.,Subramanian, Romesh,McSwiggen, James,Lee, Jeannie T.
申请号：
AU2013262663
公开号：
AU2013262663A1
申请日:
2013.05.16
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided.
