compound, pharmaceutical composition, glucokinase activator, use of a compound, methods for activating glucokinase, and for treating and / or preventing a disease
HIROYUKI TSURUOKA,MANABU ABE,MASATOSHI HONZUMI,SATORU KANEKO,TAISHI YOSHIDA
申请号：
BR112013023054
公开号：
BR112013023054A2
申请日:
2012.03.08
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a C 1 -C 6 alkyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group B, or the like； X represents a single bond, an oxygen atom, a sulfur atom, or the like； R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, or the like； R 3 represents a 1H-tetrazol-5-yl group or a 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl group； Substituent Group A represents the group of substituents selected from a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a hydroxy group, a C 1 -C 6 hydroxyalkyl group, or the like； and, Substituent Group B represents the group of substituents selected from a halogen atom, a C 3 -C 6 cycloalkyl group that may be substituted with one C 1 -C 6 hydroxyalkyl group, a hydroxy group, a C 1 -C 6 alkoxy group, a C 2 -C 7 alkylcarbonyl group, a C 2 -C 7 alkoxycarbonyl group, or the like].
