Compound, glucokinase activator, pharmaceutical composition, use of a pharmaceutically acceptable salt or compound thereof, and methods of activating glucokinase, and to treat and / or prevent a disease.
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R 1 represents, for example, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group or a C 1 -C 6 halogenated alkyl group, A and R 1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group ±, R 2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group ± or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group ±, R 3 represents a hydroxy group or a C 1 -C 6 alkoxy group, and Substituent Group ± consists of, for example, a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 alkyl group substituted with 1 or 2 hydroxy group(s), a C 1 -C 6 alkylsulfonyl group, and a group represented by the formula -V-NR 5 R 6 (wherein, V represents a carbonyl group or a sulfonyl group, and R 5 and R 6 may be the same or different and respectively represent a hydrogen atom or a C 1 -C 6 alkyl group, or R 5 and R 6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C 1 -C 6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].
