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נגזרות 11–מותמרות של 8,7–דיפלואורו–11,6–דיהידרובנזו[b,e]תיאפין
专利权人:
SHIONOGI and CO. LTD.;Makoto KAWAI;Kenji TOMITA;Toshiyuki AKIYAMA;Azusa OKANO;Masayoshi MIYAGAWA
发明人:
Makoto KAWAI,Kenji TOMITA,Toshiyuki AKIYAMA,Azusa OKANO,Masayoshi MIYAGAWA
申请号:
IL25529517
公开号:
IL255295A
申请日:
2017.10.26
申请国别(地区):
IL
年份:
2019
代理人:
摘要:
The present inventon provides the following compounds having anti-viral activity. A 1 is CR 1A R 1B , S or O; A 2 is CR 2A R 2B , S or O; A 3 is CR 3A R 3B , S or O; A 4 is CR 4A R 4B , S or O; the number of hetero atoms among atoms constituting the ring which consists of A 1 , A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 1 , is 1 or 2; R 1A and R 1B are each independently hydrogen, halogen, alkyl, or the like; R 2A and R 2B are each independently hydrogen, halogen, alkyl, or the like; R 3A and R 3B are each independently hydrogen, halogen, alkyl, or the like; R 4A and R 4B are each independently hydrogen, halogen, alkyl, or the like; R 3A and R 3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle; X is CH 2 , S or O; R 1 is each independently halogen, hydroxy, or the like; m is any integer of 0 to 2; and n is any integer of 1 to 2.
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