JUERGEN WICHMANN,JUERGEN WICHMANN,RAINER E. MARTIN,RAINER E. MARTIN,RAVI JAGASIA,RAVI JAGASIA,ROLAND JAKOB-ROETNE,ROLAND JAKOB-ROETNE,SIMONA M. CECCARELLI,SIMONA M. CECCARELLI
申请号：
BR112015027362
公开号：
BR112015027362A2
申请日:
2014.04.30
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
patent summary: "neurogenesis stimulating isoquinoline derivatives". The present invention relates to the use of compounds of formula I wherein R1 is phenyl or pyridinyl which are optionally substituted by halogen, cyano or halogen substituted alkyl or is dihydro-pyran-4-yl； R2 is hydrogen or lower alkyl； R3 is - (chr) n-phenyl, optionally substituted by lower alkoxy or s (o) 2-lower alkyl, or is heterocycloalkyl, optionally substituted by = lower alkyl, or is - (ch2) n-heteroaryl of five or six optionally substituted by lower alkyl, or is hydrogen, lower alkyl, halogen substituted lower alkyl, hydroxy substituted lower alkyl, -nr-s (o) 2-lower alkyl, - (ch2) n-cycloalkyl or - (ch2 ) ns (o) 2-lower alkyl； or R 2 and R 3 form together with the n atom to which they are attached a heterocycloalkyl ring selected from the group consisting of 1,1-dioxothiomorpholinyl, morpholinyl, or pyrrolidinyl, optionally substituted by hydroxyl； R is hydrogen or lower alkyl； n is 0, 1 or 2； or a pharmaceutically acceptable acid addition salt, racemic mixture or its corresponding enantiomer and / or optical isomers thereof, for the treatment of schizophrenia, obsessive compulsive personality disorder, depression, bipolar disorder, anxiety disorder, aging normal, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, posttraumatic stress disorder, panic disorder, parkinson's disease, dementia, alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction ("chemocerebral") ), down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, huntington's disease, stroke, and disorders due to radiation therapy, chronic stress, optic neuropathy or macular degeneration, or abuse of neuroactive drugs, t al as alcohol, opiates, methamphetamine, phenyclidine or cocaine.resumo patente de invenção: "derivados de isoquinolina estimulantes de neurogênese". a presente invenção
