Ajou University Industry-Academic Cooperation Foundation
发明人:
Yong Sung Kim,Ye Jin Kim,Keunok Jung,Jeong-Ah Kim
申请号：
US16645007
公开号：
US20200276328A1
申请日:
2018.09.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a composition for inhibiting regulatory T cell immunosuppression, containing a fusion protein comprising a peptide that binds specifically to neuropilin 1 (NRP1). The fusion protein comprising the peptide that binds specifically to neuropilin 1 according to the present invention can reduce the proportion of regulatory T cells among CD4+ T cells in tumor tissue and inhibit the activity of regulatory T cells that infiltrated into tumor tissue, thereby down-regulating immunosuppression in the tumor tissue without causing systemic toxicity. Thus, the fusion protein can exhibit a high effect on tumor treatment.
