ZHAO, ROBERT YONGXIN,YANG, QINGLIANG,HUANG, YUANYUAN,GAI, SHUN,ZHAO, LINYAO,YE, HANGBO,GUO, HUIHUI,TONG, QIANQIAN,CAO, MINJUN,JIA, JUNXIANG,YANG, CHENGYU,LI, WENJUN,ZHOU, XIAOMAI,XIE, HONGSHENG,LIN, C
申请号：
CA3013412
公开号：
CA3013412A1
申请日:
2016.02.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed are linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxie agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. Also disclosed are methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
