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SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF
专利权人:
SUZHOU M-CONJ BIOTECH CO., LTD.;Robert Yongxin Zhao;HANGZHOU DAC BIOTECH CO, LTD
发明人:
Robert Yongxin Zhao,Qingliang Yang,Yuanyuan Huang,Shun Gai,Linyao Zhao,Hangbo Ye,Huihui Guo,Qianqian Tong,Minjun Cao,Junxiang Jia,Chengyu Yang,Wenjun Li,Xiaomai Zhou,Hongsheng Xie,Chen Lin,Zhixiang Gu
申请号:
US16074981
公开号:
US20200215206A1
申请日:
2016.02.04
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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