Suzhou M-conj Biotech Co., Ltd;Dr. Robert Yongxin Zhao
发明人:
Robert Yongxin Zhao
申请号：
US14799666
公开号：
US20150322155A1
申请日:
2015.07.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to novel acetylenedicarboxyl linkers used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
