Craig D. Ostrander;David W. Taft;Robert J. Rosler;Steven D. Levin;Katherine E. Lewis;Anitra Wolf;Megan M. Lantry;Margaret D. Moore
发明人:
Steven D. Levin,Margaret D. Moore,Craig D. Ostrander,Katherine E. Lewis,David W. Taft,Robert J. Rosler,Anitra Wolf,Megan M. Lantry
申请号：
US13701234
公开号：
US08822642B2
申请日:
2011.06.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compositions and methods relating to soluble dimeric proteins are disclosed. The dimeric proteins comprise first and second polypeptide fusions linked via a dimerizing domain, each polypeptide fusion comprising first and second monomer domains corresponding to a cytokine or an extracellular domain of a cell-surface receptor. The monomer domains may be positioned amino terminal and carboxyl terminal to the dimerizing domain. Alternatively, the monomer domains may be positioned in tandem, either carboxyl terminal or amino terminal to the dimerizing domain. The dimeric proteins are useful in methods for therapy, diagnosis, and research.
