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ENHANCED EXPRESSION OF PICORNAVIRUS PROTEINS
专利权人:
发明人:
Michael J. MASSARE
申请号:
US14202338
公开号:
US20140271697A1
申请日:
2014.03.10
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The disclosure provides fusion proteins containing N-terminal signal peptides fused to immunogenic polypeptides. The immunogenic polypeptides may be from viruses, bacteria, or fungi. The disclosure also provides elevated expression of the immunogenic polypeptides using the N-terminal signal peptide. The N-terminal signal peptides enhance synthesis of the protein, particularly where the protein is neither a secretory nor a transmembrane peptide. The fusion proteins may be used to diagnose disease and to induce immune responses.
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