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Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
专利权人:
Zhongli Gao;Ryan Hartung;Daniel Hall
发明人:
Zhongli Gao,Daniel Hall,Ryan Hartung
申请号:
US13527147
公开号:
US08604046B2
申请日:
2012.06.19
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I).wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor are disclosed.
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