Calimmune, Inc.;The Regents of the University of California
发明人:
BRETON, Louis Randall,CHEN, Irvin,AN, Dong Sung,SYMONDS, Geoffrey P.,BOYD, Maureen,MILLINGTON, Michelle L.
申请号：
ES17197440
公开号：
ES2770627T3
申请日:
2010.05.26
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
