Double vector for inhibiting human immunodeficiency virus

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专利权人:

Calimmune, Inc.;The Regents of The University of California

发明人:

BRETON, Louis Randall,SYMONDS, Geoffrey P.,MILLINGTON, Michelle L.,CHEN, Irvin,AN, Dong Sung,BOYD, Maureen

申请号：

DK17197440

公开号：

DK3329772T3

申请日:

2010.05.26

申请国别(地区):

DK

年份:

2020

代理人:

摘要：

The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.

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