CHEN, IRVIN,AN, DONG SUNG,MILLINGTON, MICHELLE,BOYD, MAUREEN,SYMONDS, GEOFFREY P.,BRETON, LOUIS RANDALL
申请号：
HK12109456.4
公开号：
HK1168509B
申请日:
2012.09.25
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
