The present invention relates to compounds of formula (I) or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein R1 is C1-C3alkyl optionally substituted with F, C3-C6cycloalkyl, C1-C3alkoxy； X represents a bond or C1-C3alkylene optionally substituted with OH, ONO, ONO2； R2 is H, OH, ONO, ONO2, C(O)OH, C(O)OC1-C3alkyl, CHO, CN, C1-C3alkoxy, OC(O)H, OC(O)-C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3 alkyl, OC1-C3alkylene-C(0)N(R6)OR<；sub >；7, S(O0-2)C1-C3alkyl, CR8=N-OR9, CR8=N-NR10R11, CR8=NR12 or CR8=N-ONO2； R3 is C1-C6alkyl optionally substituted with F, OH, ONO, ONO2, C1-C3alkoxy, C3-C6cycloalkyl； C3-C6cycloalkyl, C2-C6alkenyl, C2-C6alkynyl； R4 is C1-C6alkyl optionally substituted with C3-C6cycloalkyl, C1-C6alkoxy, F, ONO, ONO2； C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl； R5 is H, SO2NR13R14, NHSO2NR13R14； R6 is H or C1-C3alkyl； R7 is H, C1-C3alkyl, C1-C3alkoxy, C1-C3alkyl substituted with phenyl, benzyl or a heterocyclic ring, wherein said phenyl, benzyl or said heterocyclic ring are independently optionally substituted by C1-C3alkyl, F； R8 is H, CH3 or C2H5； R9: H, C1-C3alkyl optionally substituted with OH, ONO, ONO2, CN, COOH, COOC1-C3alkyl, C1-C3alkoxy, OC(O)H, OC(O)-C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3 alkyl, OC1-C3alkylene-C(O)N(R6)OR<；sub >；7, S(O0-2)C1-C3alkyl； R10 and R11 are each independently H, C1-C3alkyl optionally substituted with OH, ONO, ONO2, CN, COOH, COOC1-C3, C1-C3alkoxy, OC(O)H, OC(O)-C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3 alkyl, OC1-C3alkylene-C(O)N(R6)OR<；sub >；7, S(O0-2)C1-C3alkyl；i or together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein preferably said heterocyclic ring is selected from aziridine, azetidine, pyrollidine, piperidine, morpholine, piperazine and homopiperazine, wherein said heterocyclic ring is optionally substituted with C1-C3 alkyl； R12 is C1-C3 alkyl
