3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES II农业专利-农业学术服务平台

发明人:: NARDI, ANTONIO,纳尔迪安东尼欧,納爾迪安東尼歐,RATCLIFFE, PAUL,拉特克里弗保尔,拉特克里弗保爾,CRAAN, TOBIAS,克朗托比雅斯,克朗托比雅斯,HERTRAMPF, TORSTEN,黑尔特朗夫特斯顿,黑爾特朗夫特斯頓,LESCH, BERNHARD,乐许贝恩哈德,樂許貝恩哈德,STEINHAGEN, HENNING,史坦哈根汉宁,史坦哈根

摘要：: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition、to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.本發明是有關於一種做為CatS/K雙重抑制劑之醯胺氧代四氫-2H-呋喃並[3.2-b]吡咯-4(5H)-基)之衍生物,其具有顯著之CatK抑制效果。也有關於一種包括這些化合物之醫藥組合物以及治療和/或預防疼痛以及相關之疾病及/或失調。