A non-invasive imaging and analysis system suitable for measuring attributes of a target, such as the blood glucose concentration of tissue, includes an optical processing system which provides a probe and reference beam. It also includes a means that applies the probe beam to the target to be analyzed, combines the probe and reference beams interferometrically and detects concurrent interferometric signals. The invention includes fitting multiple sets of concurrently acquired data to a profile template and calculating a variance between the profile template and the acquired data sets. It further includes refining the profile template to minimize the variance between at least some of the concurrently acquired data sets to generate a refined profile, correlating the refined profile with data from a data bank stored in memory and processing resulting correlation data to determine an attribute of the target.
