5-[3-(2,5-DICHLORO-4,6-DIMETHYL-1-OXY-PYRIDIN-3-YL)- [1,2,4]OXADIAZOL-5YL]-2-HYDROXY-3-METHOXY-1-NITROBENZENE AS AN INTERMEDIATE TO PREPARE A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

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专利权人:

BIAL - PORTELA & C.A.; S.A.

发明人:

RUSSO, DOMENICO,KISS, LASZLO ERNO,WAHNON, JORGE BRUNO REIS,LEARMONTH, DAVID ALEXANDER,ESZENYI, TIBOR,ZIMMERMAN, AXEL,SCHLUMMER, BJOERN,KREIS, MICHAEL,REITER, KLAUS

申请号：

CA3088684

公开号：

CA3088684A1

申请日:

2012.12.12

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

There is disclosed a methylated intermediate which may be demethylated toprovide aninhibitor of catechol-O-methyltransferase useful in the treatment ofParkinson's disease.Also disclosed are methods of making and using said intermediate.(see formula I)

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