A Chemical entity comprising the sulphamate Compound {(1S, 2S, 4R) - 4 - [(3 - [(1R, 2S) - 5 - Chloro - 2 - methoxy - 2,3 Dihydro 1h inden - triazin-1-yl] amino} pyrimidin-4-yl) oxy] - 2 - hidroxiciclopentil} Methyl； inhibitor of the Activation of the Enzyme SDDS - 8； Crystalline form of the compound I； prodrug； dosage composition Utica； a method for treating cancer.
SELLS, TODD B.,MCCARRON, ASHELEY SUE,STIRLING, MATTHEW,STROUD, STEPHEN G.
申请号：
CL2014000441
公开号：
CL2014000441A1
申请日:
2014.02.24
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1 S ,2 S ,4 R )-4-[(6-{[(1 R ,2 S )-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.COMPUESTO SULFAMATO DE {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-CLORO-2-METOXI-2,3-DIHIDRO-1H-INDEN-1-IL]AMINO}PIRIMIDIN-4-IL)OXI]-2-HIDROXICICLOPENTIL}METILO Y SU SAL CLOHIDRATO EN FORMA CRISTALINA； METODOS DE PREPARACION； COMPOSICION FARMACEUTICA； Y SU USO PARA TRATAR EL CANCER.
