GLAXOSMITHKLINE LLC;KINEMED INC.;Leonard S. Michael
发明人:
Michael S. Leonard
申请号：
US14363779
公开号：
US20140353486A1
申请日:
2012.12.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is based on the finding that enrichment of D3-creatinine in a urine sample following oral administration of a single defined dose of D3-creatine can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and D3-creatinine in a single sample. The methods of the invention find use, inter alia, in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass.
