Jakobovits, Aya,Raitano, Arthur B,Challita-Eid, Pia M,Jia, Xiao-Chi,Gudas, Jean,Morrison, Robert Kendall,Shao, Hui,Morrison, Karen Jane Meyrick
申请号：
NO20110647
公开号：
NO341404B1
申请日:
2011.04.29
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response； antibodies or T cells reactive with PSCA can be used in active or passive immunization.
