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NEW DIAZENIO DIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
专利权人:
LES LABORATOIRES SERVIER
发明人:
CORDI, ALEXIS,HABERKORN, LAURE,VERBEUREN, TONY,COURCHAY, CHRISTINE,SIMONET, SERGE
申请号:
ES08872697
公开号:
ES2371699T3
申请日:
2008.12.10
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compounds of formula (I): where: R1 represents a hydrogen atom or a -COOR group, R representing a linear or branched (C1-C6) alkyl or linear or branched (5 C1-C6) alkyl group; R2 represents a group G or a linear or branched (C1-C6) alkyl group substituted with a group G, G representing a group - (CH2) nA- (CH2) mB- (CR4R5) p- (CH2) or -R6, in which: * n is equal to 0, 1, 2 or 3, * m is equal to 0, 1, 2 or 3, * p is equal to 0 or 1, * or is equal to 0, 1 or 2; * R4 and R5, the same or different, represent in each case a hydrogen atom or a linear or branched (C1-C6) alkyl group, one of the groups -CH2- or -CR4R5- of the G chain being also substituted, if desired, with a phenylene group, -PhC (O) - or -PhC (O) O- (being Ph phenyl); * A and B, the same or different, represent in each case a bond, -NH- or a group: where R7 represents a hydrogen atom or a linear or branched (C1-C6) alkyl group; * and R6 represents a group where R8, R9 and R10, the same or different, represent in each case a hydrogen atom or a linear or branched (C1-C6) alkyl group, unsubstituted or substituted with an amino group, or R8 and R9 together form a linear or branched (C1-C6) alkylene chain; R3 represents a hydrogen atom, a linear or branched (C1-C6) alkyl group or a NO2 group; its enantiomers and diastereoisomers and also its addition salts of a pharmaceutically acceptable acid or base.Compuestos de fórmula (I): donde: R1 representa un átomo de hidrógeno o un grupo -COOR, representando R un grupo alquilo(C1-C6) lineal o ramificado o arilalquilo(5 C1-C6) lineal o ramificado; R2 representa un grupo G o un grupo alquilo(C1-C6) lineal o ramificado sustituido con un grupo G, representando G un grupo -(CH2)n-A-(CH2)m-B-(CR4R5)p-(CH2)o-R6, en el que: * n es igual a 0, 1, 2 o 3, * m es igual a 0, 1, 2 o 3, * p es igual a 0 o 1, * o es igual a 0, 1 o 2; * R4 y R5, iguales o diferentes, representan en cada caso un átomo de hidrógeno o un grupo alquilo(C1-C6) lineal o ramificado, pudiendo uno de los grupo
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