ANDERSON JAMES THOMAS,CHEKLER EUGENE LVOVICH PIATNITSKI,ELLSWORTH EDMUND LEE,ERICKSON BRUCE KIPP,GILBERT ADAM MATTHEW,RICKETTS ANTHONY P,THOMPSON DAVID P,UNWALLA RAYOMAND J,VERHOEST PATRICK ROBERT
申请号：
CO15126416
公开号：
CO7400864A2
申请日:
2015.06.02
申请国别(地区):
CO
年份:
2015
代理人:
摘要：
The present Invention relates to a compound of Formula 1, 2 or 3: where a is n or u2013cr0 u2013 u2013, where R0 is Hydrogen, linear or branched chain Alkyl of C1 - C6, etc., Z is u2013cre u2013 u2013, or u2013n u2013 u2013, where re is Hydrogen, oramificada linear chain Alkyl of C1 - C6 etc.； r1 is Hydrogen, alkyl or cadenalineal branched C1 - C6, etc.； R2 are independientementehidr u00f3geno or linear or branched chain Alkyl of C1 - C6 R4； r3y are independently Hydrogen, alkyl or cadenalineal branched C1 - C6, etc.； R5 and R6 sonindependientemente Hydrogen or linear chain Alkyl of C1 - C6 oramificada, R8 is Hydrogen, etc.； 1 cadenalineal or branched C1 - C6, etc.Sonindependientemente Hydrogen； R9 and R10 or oramificada linear chain Alkyl of C1 - C6, etc. u2013 u2013co u2013 u2013； Q is - (CH2), q u2013 u2013, q u2013 u2013 (CHRS) - or - (q u2013 u2013 crsrt), where RS and RT sonindependientemente linear or branched chain Alkyl Dec1 - C6, aryl, heteroaryl or alkylaryl, where q is alquilheteroarilo； 0, 1, 2, or 3； and where n is 0, 1, 2, 3, 4 or 5； or, a Salt farmac u00e9 Uticamente acceptable thereof,Paracomposiciones containing such Compounds； and to Safeguard such compounds in the treatment of diversasenfermedades, particularly those affected mediadaspor or the androgen receptorLa presente invención se refiere a un compuesto dela Fórmula 1, 2 ó 3: en donde A es N o –CR0––, donde R0 es hidrógeno, alquilo decadena lineal o ramificada de C1-C6, etc., Z es –CRe––, o,–N––, donde Re es hidrógeno, alquilo de cadena lineal oramificada de C1-C6, etc.； R1 es hidrógeno, alquilo de cadenalineal o ramificada de C1-C6, etc.； R2 son independientementehidrógeno o alquilo de cadena lineal o ramificada de C1-C6； R3y R4 son independientemente hidrógeno, alquilo de cadenalineal o ramificada de C1-C6, etc.； R5 y R6 sonindependientemente hidrógeno o alquilo de cadena lineal oramificada de C1-C6, etc.； R8 es hidrógeno, alquilo de cadenalineal o ramificada de C1-C6, etc.； R9 y R10 so
