The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or -CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.； R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl； R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.；. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.； R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.； Q is --CO--, --(CH2 )q --, --(CHRS )q --, or -(CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2, or 3； and, where n is 0, 2, 3, 4 or 5； or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds； and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.
