The neuter which does not have the times which as for this invention, do not cause strange feeling when using there to be a transparency, give the injury to the angular conjunctiva of the dry eye patient - the rebamipido instillation liquid of weak acidic pH is offered. The water suspension solution of the rebamipido crystal which possesses the transparency which is improved can obtain the rebamipido aqueous solution or the aqueous solution of the rebamipido salt which is made to melt in acid aqueous solution such as the hydrochloric acid which at least contains the chemical compound of 1 where it is selected from water solubility the macromolecule and the surface active agent kinds, with base such as sodium hydroxide by mixing.本発明は、使用時に違和感を生じない程度の透明性があり、ドライアイ患者の角結膜に傷害を与えることのない中性~弱酸性のpHのレバミピド点眼液を提供する。改善された透明性を有するレバミピド結晶の水性懸濁溶液は、水溶性高分子および界面活性剤から選択される少なくとも1種の化合物を含有する塩酸等の酸水溶液に、水酸化ナトリウム等の塩基によって溶解させたレバミピド水溶液またはレバミピド塩の水溶液を混和することにより得られる。
