1. A method of obtaining a vaccine against bacterial pathogens that produce an AV-toxip, which (a) cultivates a pathogep under the conditions under which an AV-toxin is produced and collect the culture； (b) cleave the AV-toxin enzymatically in vitro and (c) combining the composition obtained in stage (b) with a pharmaceutically acceptable carrier. The method according to claim 1, wherein inositol phosphate, preferably inositol hexaphosphate, is used as a cofactor of enzymatic digestion. The method of claim 1, wherein the cells are separated from the culture medium after collection and the AV toxin is cleaved in the culture medium. The method according to claim 3, wherein the AV toxin is purified from the collected product, preferably from the culture medium, before cleavage. The method according to claim 1, wherein the pathogen belongs to the genus Clostridium, preferably C. difficile, C.sordellii, C. botulinum, C. perfringens, C. tetani or C. novyi, or the genus Vibrio, preferably V. cholerae, V. parahaemolyticus, V.vulniflcus, V.splendidus or V.anguillarum, or the genus Xenorhabdus, preferably X.nematophila, X. bovienii, or the genus Yersinia, preferably Y. pseudotuberculosis, Y. pestis, Y.enterocolitica or Y.mollaretti, or Bordetella, preferably B.pertussis, B.parapertussis, or B.bronchiseptica, or the genus Actinobacillus, preferably A.pleuropneumoniae or A.suis, and E. coli. 6. The method of claim 5, wherein the pathogen is Clostridium difficile and toxin A are purified from toxin B before cleavage. The method of claim 1, wherein an adjuvant is added to the composition. The vaccine obtained using the method according to claims 1 to 7.9. The vaccine of claim 8, containing Toxoid A and / or Toxoid B of Clostridium difficile. Clostridium-induced diarrhea vaccine containing Toxoid A and / or Toxoid B Clostridium difficile, where Toxoid A and / or Toxoid B are derived from Toxin A and / or Toxin B by autocatal1. Способ получения вакцины против бактериальных патогено
