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METHOD OF PREPARING DABIGATRAN ETEXILATE INTERMEDIATE AND INTERMEDIATE COMPOUND
专利权人:
Shanghai Institute Of Pharmaceutical Industry;China State Institute of Pharmaceutical Industry;Chia Tai Tianqing Pharmaceutical Group Co.,Ltd
发明人:
GUO, Yajun,SHAN, Hanbin,ZHU, Xueyan,YUAN, Zhedong,YU, Xiong,GUO, Meng,HU, Mingtong,WANG, Duzheng
申请号:
EP20140896440
公开号:
EP3165521(A1)
申请日:
2014.07.03
申请国别(地区):
欧洲专利局
年份:
2017
代理人:
摘要:
Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C 1 -C 3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X = chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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