Sarah Schmidt,Klaus Orlinger,Sandra Stephanie Ring,Lukas Roland Flatz
申请号：
US16347501
公开号：
US20200206334A1
申请日:
2017.11.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present application relates generally to genetically modified arenaviruses that are suitable vaccines against neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable as vaccines and/or for treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus in combination with a chemotherapeutic agent, wherein the arenavirus has been engineered to include a nucleotide sequence encoding a tumor antigen, tumor associated antigen or antigenic fragment thereof.
