Using neutral endopeptidase-associated molecules for treatment, diagnosis, prophylaxis and monitoring of eating and metabolic disorders and dementia, also for drug development
WALTHER, THOMAS,MELZIG, MATTHIAS F.,SIEMS, WOLF E.
申请号：
DE20031011984
公开号：
DE10311984(A1)
申请日:
2003.03.12
申请国别(地区):
德国
年份:
2004
代理人:
摘要：
Use of NEP (= neutral endopeptidase)-associated molecules (I) to prepare a composition for diagnosis, prophylaxis, (secondary) treatment, and/or monitoring of non-immunological, non-hypertensive diseases of civilization. Independent claims are also included for: (1) use of NEP-modified systems for investigation and/or development of agents for diagnosis, prophylaxis, (secondary) treatment, and/or monitoring of the specified diseases; (2) cosmetic treatment of eating disorders; (3) early diagnosis of concealed eating disorders; (4) identifying molecules that are deregulated by defective or increased NEP activity; (5) identifying NEP-target peptide hormones (X); (6) deregulated (X) obtained by method (5); (7) kit comprising modulators, stimulators, agonists, inhibitors, antagonists, recognition molecules, substrates and/or substrate inhibitors (Y) of NEP; (8) device that carries immobilized (Y); (9) non-human mammal that contains at least one NEP expression cassette; and (10) breeding non-human mammals that express NEP, peripherally or centrally.
