抗體藥物複合體农业专利-农业专业知识服务系统

发明人:: LIN, NAN-HORNG,林　南宏,TSAI, CHARNG-SHENG,蔡长昇,蔡長昇,HUNG, TING-CHUN,洪鼎钧,洪鼎鈞,CHUANG, HONG-YANG,庄宏扬,莊宏揚,林南宏

摘要：: An antibody-drug conjugate (ADC) has a structure represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody without glycans (i.e., the protein portion of an antibody)； G1and G2are glycanmoieties, which may be the same or different； Cn1and Cn2are conjugation moieties, which may be the same or different； L1and L2are linker moieties, which may be the same or different； D1and D2are drug units which may be the same or different； and x and y are independently an integer from 0 to 8, provided that x + y ≠ 0.本揭示內容提供一種抗體藥物複合體(antibody-drug conjugate, ADC)，包括如式(I)所示之結構或其藥學上可接受之鹽類：其中， Ab為不具醣基之抗體(即為抗體的蛋白質部分)； G1及G2可為相同或不同之醣單元； Cn1及Cn2可為相同或不同之複合單元； L1和L2可為相同或不同之連結單元； D1和D2可為相同或不同的藥物單元；以及在x + y ≠ 0的前提下，x和y係獨立為0至8之整數。