ANTIBODY-DRUG CONJUGATES

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专利权人:

CHO Pharma Inc.

发明人:

Nan-Horng Lin,Charng-Sheng Tsai,Ting-Chun Hung,Hong-Yang Chuang

申请号：

US15812811

公开号：

US20180133340A1

申请日:

2017.11.14

申请国别(地区):

US

年份:

2018

代理人:

摘要：

An antibody-drug conjugate (ADC) has a structure represented by Formula (I):[D2-L2-Cn2yG2-Ab-Sg1G1-L1-D1]x   Formula (I)or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody without glycans (i.e., the protein portion of an antibody)；G1 and G2 are glycan moieties, which may be the same or different；Cn1 and Cn2 are conjugation moieties, which may be the same or different；L1 and L2 are linker moieties, which may be the same or different；D1 and D2 are drug units which may be the same or different； andx and y are independently an integer from 0 to 8, provided that x+y≠0.

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