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COMPOSITION OF MULTIVALENT PNEUMOCOCIC PROTEIN POLYESACARIDE CONJUGATE
专利权人:
WYETH
发明人:
WILLIAM P. HAUSDORFF,GEORGE RAINER SIBER,PETER R. PARADISO,A. KRISHNA PRASAD,HAUSDORFF WILLIAM P,SIBER GEORGE RAINER,PARADISO PETER R,A. KRIS
申请号:
BRPI0720738
公开号:
BRPI0720738A2
申请日:
2007.12.14
申请国别(地区):
BR
年份:
2014
代理人:
摘要:
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.
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中国工程科技知识中心
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