FUSED 1,4-OXAZEPINES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,ZHOU, BING,HU, YANG,YANG, CHAO-YIE,QIN, CHONG

申请号：

CA3014644

公开号：

CA3014644A1

申请日:

2017.02.15

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present disclosure provides fused 1,4-oxazepines and related analogs represented by Formula (I) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, A, and Y are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer.

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