RECEPTEURS D'ANTIGENES CHIMERIQUES SPECIFIQUES DE L'ANTIGENE DE MATURATION DES CELLULES B (BCMA)

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专利权人:

MEMORIAL SLOAN KETTERING CANCER CENTER;JUNO THERAPEUTICS, INC.

发明人:

SATHER, BLYTHE D.,SMITH, ERIC L.,AMIN, RUPESH,CHEN, AYE,HARRINGTON, KIMBERLY,HAUSKINS, COLLIN,HESS, ERIK,DE IMUS, CYR,JONES, JON,OLSHEFSKY, AUDREY,PONKO, STEFAN,SALMON, RUTH,TAREEN, SEMIH,WU, REBECCA

申请号：

CA3082010

公开号：

CA3082010A1

申请日:

2018.11.01

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided herein are chimeric antigen receptors (CARs), comprising an extracellular BCMA-binding domain, in particular a scFv. The CAR also comprises a spacer of at least 125 amino acids in length, a transmembrane domain, and an intracellular signaling region. It may also include an intracellular costimulatory domain. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

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http://www.ckcest.cn/home/