Chimeric antigen receptors specific for B-cell maturation antigen (BCMA)

• 收藏
• 分享

专利权人:

Memorial Sloan Kettering Cancer Center;Juno Therapeutics, Inc.

发明人:

SATHER, Blythe D.,SMITH, Eric L.,AMIN, Rupesh,CHEN, Aye,HARRINGTON, Kimberly,HAUSKINS, Collin,HESS, Erik,DE IMUS, Cyr,JONES, Jon,OLSHEFSKY, Audrey,PONKO, Stefan,SALMON, Ruth,TAREEN, Semih,WU, Rebecca

申请号：

AU2018360800

公开号：

AU2018360800A1

申请日:

2018.11.01

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Provided herein are chimeric antigen receptors (CARs), comprising an extracellular BCMA-binding domain, in particular a scFv. The CAR also comprises a spacer of at least 125 amino acids in length, a transmembrane domain, and an intracellular signaling region. It may also include an intracellular costimulatory domain. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/