SONG, DAE HAE,LIM, CHANG KI,SONG, TAE HUN,KIM, YOUNG HOON,KWON, SE CHANG,LEE, GWAN SUN,JUNG, SUNG YOUB,CHOI, IN YOUNG
申请号：
MYPI 20092818
公开号：
MY164479A
申请日:
2008.01.04
申请国别(地区):
MY
年份:
2017
代理人:
摘要：
THE PRESENT INVENTION RELATES TO AN INSULINOTROPIC PEPTIDE CONJUGATE HAVING IMPROVED IN-VIVO DURATION OF EFFICACY AND STABILITY, COMPRISING AN INSULINOTROPIC PEPTIDE, A NON-PEPTIDE POLYMER AND AN IMMUNOGLOBULIN FC REGION, WHICH ARE COVALENTLY LINKED TO EACH OTHER, AND A USE OF THE SAME. THE INSULINOTROPIC PEPTIDE CONJUGATE OF THE PRESENT INVENTION HAS THE IN-VIVO ACTIVITY WHICH IS MAINTAINED RELATIVELY HIGH, AND HAS REMARKABLY INCREASED BLOOD HALF-LIFE, AND THUS IT CAN BE DESIRABLY EMPLOYED IN THE DEVELOPMENT OF LONG ACTING FORMULATIONS OF VARIOUS PEPTIDE DRUGS. (FIGURE 13)
