Chang Ki Lim;Tae Hun Song;Young Hoon Kim;Sung Youb Jung;Gwan Sun Lee;In Young Choi;Dae Hae Song;Se Chang Kwon
发明人:
Dae Hae Song,Chang Ki Lim,Tae Hun Song,Young Hoon Kim,Se Chang Kwon,Gwan Sun Lee,Sung Youb Jung,In Young Choi
申请号：
US12523050
公开号：
US08476230B2
申请日:
2008.01.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
