isolated nucleic acid sequence, isolated chimeric antigen receptor, cell, vector, and methods for stimulating a t-cell mediated immune response, for providing antitumor immunity in a mammal, for treating a mammal having a disease, disorder or condition, and to treat a human with a disease
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
