您的位置: 首页 > 农业专利 > 详情页

CAR EXPRESSION VECTOR AND CAR-EXPRESSING T CELLS
专利权人:
YAMAGUCHI UNIVERSITY
发明人:
TAMADA, Koji,SAKODA, Yukimi,ADACHI, Keishi
申请号:
PH12017500596
公开号:
PH12017500596B1
申请日:
2017.03.31
申请国别(地区):
PH
年份:
2017
代理人:
摘要:
The present invention addresses the problem of providing chimeric antigen receptor (CAR)-expressing T cells that express a CAR and also express a T cell immunological function promoting factor, and that have a strong immunity-inducing effect and high antitumor activity. The present invention also addresses the problem of providing a CAR expression vector for producing such CAR-expressing T cells. This CAR expression vector contains a nucleic acid that codes for a CAR, and a nucleic acid that codes for a T cell immunological function promoting factor, wherein the nucleic acid that codes for the T cell immunological function promoting factor comprises either: the nucleic acid that codes for interleukin-7 and the nucleic acid that codes for CCL19; a nucleic acid that codes for a dominant-negative mutant of SHP-1; or a nucleic acid that codes for a dominant-negative mutant of SHP-2. CAR-expressing T cells into which said CAR expression vector has been introduced are produced.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充