Pyrethroid-2 (1H) - a drug used to treat diffuse trochanter, rejection of transplantation, immune system mediated diseases and inflammation of the gallbladder
EASTWOOD, PAUL ROBERT,GONZALEZ RODRIGUEZ, JACOB,GOMEZ CASTILLO, ELENA,BACH TANA, JORDI
申请号：
PE2013002502
公开号：
PE20141010A1
申请日:
2012.05.21
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to formula compound (I): m is 0, 1, 2 or 3； x E is independent n, or Cr5, wherein at least one x E represents Cr5, R5 represents h, halide, cyanide, etc.； a and B are independent n or Cr6, where at least one x E represents Cr6； W is the can body selected from N7, s, or, inter Alia, R7 generation table H, C1-C4 halide, C1-C4 hydrochloric acid, C1-C4, etc.； R1 is h, linear tar or branch C1-C6, C1-C4 halide, C1-C4 hydrochloric acid, C1-C4, etc.； R2 and R6 are independent h, halogenation, cyanogen, linear tar or C1-C6 derivatives； R3 and R4 are independent h, C1-C4 halotar, C1-C4, C1-C4 hydrochemistry C1-C4,1. C1-C6 linear or branched tar, in which C1-C6 group is not replaced or replaced by one or more substitutes. The preferred compounds are: 2 - (2-oxo-1, 2-dihydropiridin-3-ilamin) - 9 - (tetrahydro-2h-piran-4-il) - 7 h-purin-8 (9h) - ona, etc. Except for a pharmaceutical composer These compounds are Janu quinxas inhibitors.Treatment of leukemia, multiple sclerosis, asthma, dry eyeREFERIDO A COMPUESTOS DE FORMULA (I) DONDE: m ES 0, 1, 2 O 3； X E Y SON INDEPENDIENTEMENTE N, O CR5, DONDE AL MENOS UNO DE X E Y REPRESENTA CR5, R5 ES H, HALOGENO, CIANO, ENTRE OTROS； A Y B ES INDEPENDIENTEMENTE N O CR6, EN DONDE AL MENOS UNO DE X E Y REPRESENTA CR6； W ES UN GRUPO ENLAZADOR SELECCIONADO DEL GRUPO NR7, S, O, ENTRE OTROS, R7 ES H, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4, ENTRE OTROS； R1 ES H, ALQUILO LINEAL O RAMIFICADO C1-C6, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4, ENTRE OTROS； R2 Y R6 SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, ALQUILO LINEAL O RAMIFICADO C1-C6, ENTRE OTROS； R3 Y R4 SON INDEPENDIENTEMENTE H, HALOALQUILO C1-C4, HIDROXIALQUILO C1-C4, ALQUILO LINEAL O RAMIFICADO C1-C6, DONDE DICHO GRUPO ALQUILO ESTA NO SUSTITUIDO O SUSTITUIDO CON UNO O MAS SUSTITUYENTES. UN COMPUESTO PREFERIDO ES: 2-(2-OXO-1,2-DIHIDROPIRIDIN-3-ILAMINO)-9-(TETRAHIDRO-2H-PIRAN-4-IL)-7H-PURIN-8(9H)-ONA, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON IN
