It refers to a compound obtained from formula (I), wherein X is or s； R1 is h, cyanogen, halide, c1-8 tar, etc.； R2 is arilo, isocyanide, etc.； R3 is h, cyanogen, halide, c1-8 tar, c1-8 halide, etc.； R4 is h, halogenation, cyanogen, c1-8 toxic oxygen, c1-8 halo-8, c1-8 halo-8, c1-8 halo-8, c1-8, etc.； R5, HL, alqueno, C8, etc. C2-8, among others； R4 and R5 together are - C (H) = C (H) - C (H) = C (H) or c1-8 tar； R6 is h, c1-8 tar, c1-8 halogen tar, alcoxilo (c1-8) - tar (c1-8),E1 is - cr7r8, among other things,Among other things, E2 es-cr11r12, among others, R7 and R8 are independent h, cyanogen and halide, which together are oxo-ch2-ch2 -；R11 and R12 are independent h, cyanogen, halide, and so on. Together, they are oxo o-ch2-ch2. - [3 - [3-3]]]]]]]]]]] - [3 - [3 - [3 - [3 - [3 - [3 6-dihydro-2h - [1, 4 - [oxazin-3-il] - phenyl] - 5-trifluoro-methyl-pyridine-2-carbulin, etc. He also mentioned a drug synthesis and a preparation procedure. The compound is a beta Secretary enzyme (bace) inhibitor for the treatment of Alzheimer's disease.SE REFIERE A UN COMPUESTO DERIVADO DE OXACINA DE FORMULA (I) DONDE: X ES O O S； R1 ES H, CIANO, HALOGENO, ALQUILO C1-8, ENTRE OTROS； R2 ES ARILO, HETEROARILO, ENTRE OTROS； R3 ES H, CIANO, HALOGENO, ALQUILO C1-8, HALOALQUILO C1-8, ENTRE OTROS； R4 ES H, HALOGENO, CIANO, ALCOXILO C1-8, HALO-ALCOXILO C1-8, ENTRE OTROS； R5 ES H, CIANO, ALQUENILO C2-8, ALQUINILO C2-8, ENTRE OTROS； R4 Y R5 JUNTOS SON -C(H)=C(H)-C(H)=C(H) O ALQUILENO C1-8, ENTRE OTROS； R6 ES H, ALQUILO C1-8, HALO-ALQUILO C1-8, ALCOXILO(C1-8)-ALQUILO(C1-8), ENTRE OTROS； E1 ES -CR7R8-, ENTRE OTROS； E2 ES -CR11R12, ENTRE OTROS； R7 Y R8 SON INDEPENDIENTEMENTE H, CIANO, HALOGENO, ENTRE OTROS, JUNTOS SON OXO O -CH2-CH2-； R11 Y R12 SON INDEPENDIENTEMENTE H, CIANO, HALOGENO, ENTRE OTROS, JUNTOS SON OXO O -CH2-CH2-. SON COMPUESTOS PREFERIDOS: [3-(5-AMINO-3-METIL-3,6-DIHIDRO-2H-[1,4]-OXAZIN-3-IL)FENIL]-AMIDA DEL ACIDO FURAN-2-CARBOXILICO； 5-METIL-[3-(5-AMINO-3-METIL-3,6-DIHIDRO-2H-[1,4
