BELL, ANDREW SIMON,BROWN, ALAN DANIEL,DE GROOT, MARCEL JOHN,LEWTHWAITE, RUSSELL ANDREW,MARSH, IAN ROGER,MILLAN, DAVID SIMON,PEREZ PACHECO, MANUEL,RAWSON, DAVID JAMES,SCIAMMETTA, NUNZIO,STORER, ROBERT
申请号：
ES11748997
公开号：
ES2532357T3
申请日:
2011.07.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: X is O； Ar1 is (i) naphthyl； or (ii) naphthyl or phenyl, each of which is independently substituted with one to three Y； Y is F； Cl； CN； (C1-C8) alkyl, optionally substituted with (C3-C8) cycloalkyl or one to three F； cycloalkyl (C3-C8), optionally substituted with one to three F； NR7R8； (C1-C8) alkyloxy, optionally independently substituted with one to three R9； cycloalkyloxy (C3-C8)； phenyl, optionally substituted independently with one to three R10； Het1 or Het2； wherein cycloalkyloxy (C3-C8) may optionally be fused to a phenyl ring or may be independently substituted with one to three R10； R1 is (C1-C6) alkyl or (C3-C8) cycloalkyl, each of which is optionally substituted with one to three F； R2, R3, R4 are independently H, F, Cl or -OCH3； R5 is H, CN, F, Cl or R6； R6 is a group selected from (C1-C6) alkyl and (C1-C6) alkyloxy, in which each group is optionally substituted, if valence permits, with one to five F； R7 and R8 are independently H； (C1-C8) alkyl, optionally independently substituted with one to three R11； cycloalkyl (C3-C8)； or Het1 "bound to C"； wherein cycloalkyl (C3-C8) may optionally be fused to a phenyl ring or may be independently substituted with one to three R10； or R7 and R8, taken together with the nitrogen atom to which they are attached, form a bridged ring, saturated from 7 to 9 members； R9 is F； (C1-C6) alkyloxy； cycloalkyl (C3-C8), optionally substituted with one to three F； Het1； or phenyl, optionally independently substituted with one to three R6； R10 is F, Cl or R6； R11 is F； (C1-C6) alkyloxy； cycloalkyl (C3-C8), optionally substituted with one to three F； Het1 "bound to C"； or phenyl, optionally independently substituted with one to three R6； Het1 is a 3 to 8-membered saturated monoheterocycloalkyl comprising one or two ring members selected from -NR12- and -O-, said monoheterocycloalkyl being optionally substituted on a ring carbon atom
