BRUNO P. HACHE,C. TODD EARY,CHRISTOPHER F. KRASER,DARREN HARVEY,DAVID A. MORENO,ELLEN LAIRD,ERIK JAMES HICKEN,JOHN E. ROBINSON,LAURENCE E. BURGESS,LI REN,MARK C. MUNSON,MARK LAURENCE BOYS,ROBERT GRONE
申请号：
BR112014008865
公开号：
BR112014008865A2
申请日:
2012.10.09
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract compounds of formula I: i and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which r1, r2, r3, r4, r5, r6, x1 and x2 have the meanings given in the specification, are inhibitors of one or more jak kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities. Abstract of Patent Summary: "5,7-substituted imidazo [1,2-c] pyrimidines". compounds of formula I: ie stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein r1, r2, r3, r4, r5, r6, x1 and x2 have the meanings given in the specification, are inhibitors of one or more jak kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as haematological disorders and malignancies and their comorbidities. 21021384v1abstract compounds of formula i: i and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which r1, r2, r3, r4, r5, r6, x1 and x2 have the meanings given in the specification, are inhibitors of one or more jak kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities. tradução do resumo resumo patente de invenção: "imidazo[1,2-c]pirimidinas 5,7-substituídas". compostos da fórmula i: i e estereoisômeros e sais farmaceuticamente aceitáveis e solvatos destes, em que r1, r2, r3, r4, r5, r6, x1 e x2 têm os significado dados no relatório descritivo, são inibidores de uma ou mais jak quinases e são úteis no tratamento de doenças autoimunes, doenças inflamatórias, rejeição de órgãos, tecidos e células transplantados, bem como distúrbios hematológicos e malignidades e suas comorbidades. 21021384v1
