A skin care composition comprises a medium that is qualified in a cosmetic filed. In the medium, vitamin B3 with additive content of 0.1% to 5%, vitamin B5 with additive content of 0.1% to 5%, and middle molecule hyaluronic acid with additive content of 0.001% to 1% are added, in which molecular weight of the middle molecule hyaluronic acid is ranged from 50,000 to 500,000. With these three major parts, including vitamin B3, vitamin B5 and middle molecule hyaluronic acid, to be added in the medium that is qualified in the cosmetic filed, viz. to compose a particular skin maintenance care content compound, skin-beautifying effects such as bright white, anti acne, repair, moisture retention and acne scar lighting for users can be obtained.一種皮膚保養組合物,其包括:一化粧品界合格之媒液,且添加:(I)維他命B3添加含量:0.1%至5%;(Ⅱ)維他命原B5添加含量:0.1%至5%;及(Ⅲ)中分子玻尿酸添加含量:0.001%至1%,該中分子玻尿酸的分子量係5萬到50萬。將維他命B3、維他命B5及中分子玻尿酸等三大成分添入化粧品界合格之媒液,組合成特殊的肌膚養護成分複方,提供使用者亮白、抗痘、修復、保濕、淡疤等美膚作用。