Neeraj Kapoor;Thomas P. Sakmar;Ruchi Gupta;Santosh T. Menon;Dan Raleigh
发明人:
Thomas P. Sakmar,Santosh T. Menon,Neeraj Kapoor,Ruchi Gupta,Dan Raleigh
申请号：
US13054263
公开号：
US08703707B2
申请日:
2009.07.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.
