VARIANTS DU FACTEUR VIII A CPG REDUIT, COMPOSITIONS, PROCEDES ET UTILISATIONS POUR LE TRAITEMENT D'AFFECTIONS HEMOSTATIQUES

• 收藏
• 分享

专利权人:

INC.;SPARK THERAPEUTICS

发明人:

ANGUELA, XAVIER,SHEN, SAM HSIEN-I

申请号：

CA3002689

公开号：

CA3002689A1

申请日:

2016.10.31

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants encoding FVIII are expressed more efficiently by cells, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced expression and/or activity over wild-type Factor VIII proteins or are packaged more efficiently into viral vectors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/