BOLLI Martin (CH),БОЛЛИ Мартин (CH),LESKOP Sirill (FR),ЛЕСКОП Сирилл (FR),MATIS Boris (CH),МАТИС Борис (CH),MJuLLER Klaus (DE),МЮЛЛЕР Клаус (DE),NAJLER Oliver (CH),НАЙЛЕР Оливер (CH),ShTAJNER Beat (CH,BOLLI MARTIN,БОЛЛИ Мартин,LESKOP SIRILL,ЛЕСКОП Сирилл,MATIS BORIS,МАТИС Борис,MJULLER KLAUS,МЮЛЛЕР Клаус,NAJLER OLIVER,НАЙЛЕР Оливер,SHTAJNER BEAT,ШТАЙНЕР Беат,FELKER JERG,ФЕЛЬКЕР Йёрг
申请号：
RU2010109542/04
公开号：
RU0002492168C2
申请日:
2008.08.14
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to novel pyridine derivatives pyridine1-A-pyridine2 of formula (1), where pyridine1 represents, , or , ,where asterisks stand for bond, which contains pyridine1 ring with A； R1 represents C1-5alkyl, C1-4alkoxygroup, C3-6-cycloalkyl, hydroxymethyl or NR1aR1b, R1a represents C1-4alkyl； R1b represents hydrogen or C1-3alkyl； or R1a and R1b, together with nitrogen atom, which is bound to pyridine, form pyrrolidine ring； R2 represents hydrogen or C1-4alkyl, or in case, when R1 represents C1-5alkyl or C3-6-cycloalkyl, R2 can additionally represent methoxygroup； R3 represents C1-4alkyl, C1-4alkoxygroup, C3-6-cycloalkyl or NR3aR3b； R3a represents C1-4alkyl； R3b represents hydrogen or C1-3alkyl； R4 represents C1-4alkyl or hydrogen； R5 represents C1-5alkyl, methoxygroup or NR5aR5b； and R6 represents C1-2alkyl； R5a represents C1-4alkyl； R5 represents hydrogen or C1-3alkyl； or R5 represents C1-2alkyl or methoxygroup； and R6 represents C1-5alkyl or NR6aR6b； R6a represents C1-4alkyl； R6b represents hydrogen or C1-3alkyl； R7 represents C1-5alkyl； R8 represents C1-2alkyl or methoxygroup； R9 represents C1-5alkyl； R10 represents C1-2alkyl； A represents, , or ,where asterisks stand for bond, binding pyridine1 ring with A； pyridine2 represents, , or , ,where asterisks stand for bond, which binds pyridine ring with A； R11 represents C1-4alkyl； C1-3alkyloxy group, hydroxymethyl or NR11aR11b； R,1a represents C1-3alkyl； R11b represents hydrogen or C1-2alkyl； R12 represents hydrogen or C1-4alkyl； R13 represents C1-4alkyl or NR13aR13b； R13a represents C1-4alkyl； R13b represents hydrogen or C1-2alkyl； R14 represents C1-2alkyl； R15 represents C1-4alkyl or NR15aR15b； and R16 represents C1-2alkyl； R15a represents C1-3alkyl； R15b represents hydrogen or C1-3alkyl； or R15 represents C1-2alkyl； and R16 represents C1-4alkyl or NR16aR16b； R16a represents C1-3alkyl； R16b represents hydrogen or C1-2alkyl； R17 represents C1-4alkyl； R18 represe
