ADAMI, ROGER, C,HOUSTON, MICHAEL, E,JOHNS, RACHEL, E
申请号：
NZ58404808
公开号：
NZ584048A
申请日:
2008.10.02
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
A lipopeptide compound of the formula R3-J-{ NRN-CR1R2-(C=O)} n-Z-R4 (Formula I). R1 is an amino acid side chain other than hydrogen { NRN-CR1R2-(C=O)} n is an amphipathic central peptide capable of binding nucleic acids, wherein n is 4 to 100 R2 and RN are hydrogen or C(1-22)alkyl R3 and R4 are lipid tails Z is NH, O or a linker J is (C=O), O or a linker. The lipopeptide can be used for delivering interfering RNA, such as siRNA or mdRNA, to a cell. The lipopetide and RNA composition can be used for inhibiting gene expression and treating cancer, a metabolic disease or disorder, an inflammatory disease or a viral infection.
