A micro needle driving device comprises: a main body having a receiving space formed therein a drive motor provided in the receiving space a rotating unit axially coupled to and rotating with the rotating shaft of the drive motor and having a guide projection formed on an outer peripheral side surface thereof and a moving cam unit having the micro needle unit coupled to a side thereof and the rotating unit received therein, having a guide portion formed in a curved line along a lengthwise direction on an inner peripheral side surface thereof, and reciprocally and linearly moved according to the rotation of the rotating unit. The guide portion has the guide projection connected thereto in a slidably movable manner.